姓 名：王俊文
性 別：男
最高學位：醫(yī)學博士
職 稱：醫(yī)師
職 務：恩施州中心醫(yī)院團委紀檢委員、湖北硒與人體健康研究元PI
mail ： [email protected], [email protected]
電 話：18695028160
研究方向：眼遺傳病
個人簡介：
王俊文，中共黨員，眼科學博士，博士畢業(yè)于中山大學中山眼科中心，是恩施州中心醫(yī)院為了加強該院眼科中心國家臨床重點專科建設和湖北省眼遺傳病臨床研究中心發(fā)展所引進的高層次和急需緊缺人才，現(xiàn)任恩施州中心醫(yī)院團委紀檢委員、湖北硒與人體健康研究院PI，專注眼遺傳病的臨床和基礎研究。
承擔的科學研究項目、教學研究項目及經(jīng)費：
恩施州中心醫(yī)院實驗室PI科研啟動項目 主持 20萬
恩施州“啟航專項”科技計劃項目 主持 6萬
恩施州中心醫(yī)院國家自然科學基金培育項目 主持 5萬
公開發(fā)表論文、教材、專著及課程建設：
1.Wang J, Li S, Jiang Y, Wang Y, Ouyang J, Yi Z, Sun W, Jia X, Xiao X, Wang P, Zhang Q. Pathogenic Variants in CEP290 or IQCB1 Cause Earlier-Onset Retinopathy in Senior-Loken Syndrome Compared to Those in INVS, NPHP3, or NPHP4. Am J Ophthalmol. 2023 Mar 27;252:188-204. doi: 10.1016/j.ajo.2023.03.025. PMID: 36990420.
2.Wang J, Wang Y, Li S, Xiao X, Yi Z, Jiang Y, Li X, Jia X, Wang P, Jin C, Sun W, Zhang Q. Clinical and Genetic Analysis of RDH12-Associated Retinopathy in 27 Chinese Families: A Hypomorphic Allele Leads to Cone-Rod Dystrophy. Invest Ophthalmol Vis Sci. 2022 Aug 2;63(9):24. doi: 10.1167/iovs.63.9.24. PMID: 35994252.
3. Wang J, Wang Y, Jiang Y, Li X, Xiao X, Li S, Jia X, Sun W, Wang P, Zhang Q. Autosomal Dominant Retinitis Pigmentosa-Associated TOPORS Protein Truncating Variants Are Exclusively Located in the Region of Amino Acid Residues 807 to 867. Invest Ophthalmol Vis Sci. 2022 May 2;63(5):19. doi: 10.1167/iovs.63.5.19. PMID: 35579903.
4.Wang J, Xiao X, Li S, Jiang H, Sun W, Wang P, Zhang Q. Landscape of pathogenic variants in six pre-mRNA processing factor genes for retinitis pigmentosa based on large in-house data sets and database comparisons. Acta Ophthalmol. 2022 Nov;100(7):e1412-e1425. doi: 10.1111/aos.15104. Epub 2022 Feb 9. PMID: 35138024.
5.Wang J, Wang Y, Jiang Y, Li S, Jia X, Xiao X, Sun W, Wang P, Zhang Q. Datasets-Based IMPDH1 Revisited: Heterozygous Missense Variants for Dominant Retinitis Pigmentosa While Truncation Variants Are Likely Non-Pathogenic. Curr Eye Res. 2024 Apr 11:1-9. doi: 10.1080/02713683.2024.2336158. Epub ahead of print. PMID: 38604988.
6.Wang J, Xiao X, Li S, Wang P, Sun W, Zhang Q. Dominant RP in the Middle While Recessive in Both the N- and C-Terminals Due to RP1 Truncations: Confirmation, Refinement, and Questions. Front Cell Dev Biol. 2021 Feb 19;9:634478. doi: 10.3389/fcell.2021.634478. PMID: 33681214.
7.Wang J, Liu F, Song X, Li T. Association of 5p15.2 and 15q14 with high myopia in Tujia and Miao Chinese populations. BMC Ophthalmol. 2020 Jun 26;20(1):255. doi: 10.1186/s12886-020-01516-8. PMID: 32586281.
8.Liu F, Wang J, Xing Y, Li T. Mutation screening of 17 candidate genes in a cohort of 67 probands with early-onset high myopia. Ophthalmic Physiol Opt. 2020 May;40(3):271-280. doi: 10.1111/opo.12683. Epub 2020 Mar 25. PMID: 32215939.
9.Wang Y, Wang J, Jiang Y, Zhu D, Ouyang J, Yi Z, Li S, Jia X, Xiao X, Sun W, Wang P, Zhang Q. New Insight into the Genotype-Phenotype Correlation of PRPH2-Related Diseases Based on a Large Chinese Cohort and Literature Review. Int J Mol Sci. 2023 Apr 4;24(7):6728. doi: 10.3390/ijms24076728. PMID: 37047703; PMCID: PMC10095211.
10.Sun W, Xiong D, Ouyang J, Xiao X, Jiang Y, Wang Y, Li S, Xie Z, Wang J, Tang Z, Zhang Q. Altered chromatin topologies caused by balanced chromosomal translocation lead to central iris hypoplasia. Nat Commun. 2024 Jun 13;15(1):5048. doi: 10.1038/s41467-024-49376-w. PMID: 38871723.
11.Zhu D, Wang J, Wang Y, Jiang Y, Li S, Xiao X, Wang P, Zhang Q. Variant Landscape of 15 Genes Involved in Corneal Dystrophies: Report of 30 Families and Comprehensive Analysis of the Literature. Int J Mol Sci. 2023 Mar 6;24(5):5012. doi: 10.3390/ijms24055012. PMID: 36902444.
12.Wang P, Wu P, Wang J, Zeng Y, Jiang Y, Wang Y, Li S, Xiao X, Zhang Q. Missense Mutations in MAB21L1: Causation of Novel Autosomal Dominant Ocular BAMD Syndrome. Invest Ophthalmol Vis Sci. 2023 Mar 1;64(3):19. doi: 10.1167/iovs.64.3.19. PMID: 36892533.
13.Jiang Y, Zhou L, Wang Y, Ouyang J, Li S, Xiao X, Jia X, Wang J, Yi Z, Sun W, Jiao X, Wang P, Hejtmancik JF, Zhang Q. The Genetic Confirmation and Clinical Characterization of LOXL3-Associated MYP28: A Common Type of Recessive Extreme High Myopia. Invest Ophthalmol Vis Sci. 2023 Mar 1;64(3):14. doi: 10.1167/iovs.64.3.24. PMID: 36917121.
14.Wang Y, Sun W, Xiao X, Jiang Y, Ouyang J, Wang J, Yi Z, Li S, Jia X, Wang P, Hejtmancik JF, Zhang Q. Unique Haplotypes in OPN1LW as a Common Cause of High Myopia With or Without Protanopia: A Potential Window Into Myopic Mechanism. Invest Ophthalmol Vis Sci. 2023 Apr 3;64(4):29. doi: 10.1167/iovs.64.4.29. PMID: 37097228.
15.Wang Y, Jiang Y, Wang J, Li S, Jia X, Xiao X, Sun W, Wang P, Zhang Q. Retinopathy as an initial sign of hereditary immunological diseases: report of six families and challenges in eye clinic. Front Immunol. 2023 Aug 28;14:1239886. doi: 10.3389/fimmu.2023.1239886. PMID: 37711606.
16.Li X, Wang Y, Wang J, Wang P, Zhang Q. Double Hyperautofluorescence Rings as a Sign of CFAP410-related Retinopathy. Invest Ophthalmol Vis Sci. 2023 Dec 1;64(15):44. doi: 10.1167/iovs.64.15.44. PMID: 38153748.
17.Guo D, Li S, Xiao X, Jiang Y, Wang Y, Jin G, Wang J, Ouyang J, Jia X, Sun W, Wang P, Zheng D, Zhang Q. Clinical and Genetic Landscape of Ectopia Lentis Based on a Cohort of Patients From 156 Families. Invest Ophthalmol Vis Sci. 2024 Jan 2;65(1):20. doi: 10.1167/iovs.65.1.20. PMID: 38190127.
18.Zheng Y, Wang Y, Jiang Y, Wang J, Li S, Xiao X, Sun W, Wang P, Zhang Q, Jia X. Variant and clinical landscape of Leber hereditary optic neuropathy based on 1516 families with mtDNA variants in a tertiary centre. Br J Ophthalmol. 2024 Feb 12:bjo-2023-323557. doi: 10.1136/bjo-2023-323557. Epub ahead of print. PMID: 38346855.
19.王俊文,肖紫云,李拓.鞏膜扣帶術(shù)治療孔源性視網(wǎng)膜脫離的療效及其對眼球生物學參數(shù)的影響[J].湖北民族大學學報(醫(yī)學版),2020,37(01):30-34.DOI:10.13501/j.cnki.42-1590/r.2020.01.008. 2020-03-20
20.王俊文,李拓.多焦視網(wǎng)膜電圖在視網(wǎng)膜疾病中的應用進展[J].國際眼科雜志,2020,20(10):1730-1735. 2020-10-08. DOI:10.3980 / j.issn.1672-5123.2020.10.14